PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data.

> 商业许可源文 · EUROPE_PMC · [CC-BY](https://creativecommons.org/licenses/by/)

书目信息

引用：Franzén O, Gan LM, Björkegren JLM. (2019). PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data. Database : the journal of biological databases and curation. PMID 30951143 · PMC6450036 · DOI 10.1093/database/baz046

证据类型：PRIMARY_RESEARCH

主题：rna-seq、single-cell

被引次数（采集时）：1330

原始记录：[Europe PMC](https://europepmc.org/article/MED/30951143)

来源许可：[CC-BY](https://creativecommons.org/licenses/by/)

作者摘要（按来源许可复用）

Single-cell RNA sequencing is an increasingly used method to measure gene expression at the single cell level and build cell-type atlases of tissues. Hundreds of single-cell sequencing datasets have already been published. However, studies are frequently deposited as raw data, a format difficult to access for biological researchers due to the need for data processing using complex computational pipelines. We have implemented an online database, PanglaoDB, accessible through a user-friendly interface that can be used to explore published mouse and human single cell RNA sequencing studies. PanglaoDB contains pre-processed and pre-computed analyses from more than 1054 single-cell experiments covering most major single cell platforms and protocols, based on more than 4 million cells from a wide range of tissues and organs. The online interface allows users to query and explore cell types, genetic pathways and regulatory networks. In addition, we have established a community-curated cell-type marker compendium, containing more than 6000 gene-cell-type associations, as a resource for automatic annotation of cell types.

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